GRANTS FOR UNDERREPRESENTED MINORITY SCIENTISTS IN DIGESTIVE DISEASES - NIH


 

Release Date:  November 22, 1999

RFA:  DK-00-007   



National Institute of Diabetes and Digestive and Kidney Diseases   



Letter of Intent Receipt Date: February 22, 2000 

Application Receipt Date: March 22, 2000   



PURPOSE

The National Institute of Diabetes and Digestive and Kidney Diseases  

(NIDDK) recognizes the need to increase the number of individuals  

from underrepresented minority groups committed to scientific  

careers in research areas served by the NIDDK.  This program is  

aimed primarily at recently trained M.D. and/or Ph.D. minority  

investigators.  The program will enable the applicant to accept a  

tenure-earning position, gain additional research experience and  

obtain preliminary data on which to base a subsequent research grant  

application in an area of diabetes, endocrinology, metabolism,  

digestive diseases, and nutrition, kidney, urology or hematology.



HEALTHY PEOPLE 2000



The Public Health Service (PHS) is committed to achieving the health  

promotion and disease prevention objectives of "Healthy People  

2000," a PHS-led national activity for setting priority areas.  This  

RFA, Support of Minorities in Diabetes, Digestive and Kidney  

Disease, is related to the priority area of increasing  

underrepresented minority health scientists.  Potential applicants  

may obtain a copy of "Healthy People 2000" at  

http://odphp.osophs.dhhs.gov/pubs/hp2000.    ELIGIBILITY 



REQUIREMENTS



For the purpose of this announcement, underrepresented minority  

investigators are defined as individuals belonging to a particular  

ethnic minority investigators are defined as individuals belonging  

to a particular ethnic or racial group has been determined by the  

grantee institution to be underrepresented in biomedical or  

behavioral research.  Awards will be limited to citizens or non- 

citizen nationals of the United States or to individuals who have  

been lawfully admitted for permanent residence (i.e., in possession  

of an Alien Registration Receipt Card) at the time of application.  



An applicant must have a doctoral degree (M.D., Ph.D., D.O., D.D.S.,  

D.V.M.).  He or she should have received at least two years of  

postgraduate research training in an area of research applicable to  

research supported in this institute.  He/she should have direct  

access to an expert in the area of the proposed research who can  

provide guidance or any necessary assistance in carrying out the  

proposed research.  Applicants may not hold, nor apply concurrently  

for any other PHS research project grant at the time of this  

application.  Priority will be given to those applicants who have  

not previously been a Principal Investigator on a major research  

grant.  Applicants are encouraged to apply for other research  

project grants during the course of, or following, this award.



MECHANISM OF SUPPORT



Support will be provided through the Small Research Grant (R03)  

program administered by the Division of Diabetes, Endocrinology and  

Metabolism, the Division of Digestive Diseases and Nutrition, and  

the Division of Kidney, Urologic and Hematologic Diseases in the  

NIDDK.  Responsibility for the planning, direction, and execution of  

the proposed project will be that of the applicant.  Awards will be  

administered under NIH grants policy as stated in the NIH Grants  

Policy Statement.



Applicants from institutions that have a General Clinical Research  

Center (GCRC) funded by the NIH National Center for Research  

Resources may wish to identify the GCRC as a resource for conducting  

the proposed research.  If so, a letter of agreement from either the  

GCRC program director or principal investigator should be included  

with the application.



This RFA is a one-time solicitation.  Future unsolicited  

continuation applications will compete with all investigator- 

initiated applications and be reviewed according to the customary  

peer review procedures.  Should the NIDDK determine that there is a  

sufficient continuing program need, a request for new applications  

will be announced.  The total project period for applications  

submitted in response to the present RFA may be for one or two  

years.  In specific circumstances resulting from the requirements of  

a particular research project and the applicant's need to acquire  

additional skills required for the project, three years may be  

requested.  Direct costs requested must not exceed $50,000 per year.   

A grant funded from this RFA cannot be renewed.  The anticipated  

award date is September 30, 2000.



Specific application instructions have been modified to reflect  

"MODULAR GRANT" and "JUST-IN-TIME" streamlining efforts being  

examined by the NIH.  Complete and detailed instructions and  

information on Modular Grant applications can be found at  

http://grants.nih.gov/grants/funding/modular/modular.htm



FUNDS AVAILABLE



For FY 2000, $250,000 in total direct costs for year 01 will be  

committed in each of the three research divisions in the NIDDK.  It  

is anticipated that up to five awards will be made in each of the  

three NIDDK program divisions in FY 2000.  This level of support  

depends on the receipt of a sufficient number of applications of  

high scientific merit.  Although this program is provided for in the  

financial plans of the NIDDK, the award of grants pursuant to this  

RFA is contingent upon the availability of funds for this purpose  

and the receipt of a sufficient number of applications of  

outstanding scientific and technical merit.



RESEARCH OBJECTIVES



The primary purpose of this RFA is to increase the number of  

underrepresented minority Principal Investigators conducting  

research in areas supported by the NIDDK.  Surveys of research and  

training programs administered by the NIDDK disclose the need to  

increase the access to NIDDK support of recently trained minority  

scientists who are U.S. citizens or permanent residents.  Those who  

receive several years of training via an individual postdoctoral  

fellowship or an institutional training grant funded by a National  

Research Service Award may still require additional research  

experience and preliminary data to support an independent research  

career at this stage of development.  An additional period of  

training may not be feasible for minority individuals with pressing  

economic burdens.  Such individuals may be lost to academic research  

through a lack of opportunity to obtain an additional one or two  

years of support essential for establishing a research career.



This program is designed to help alleviate some of the above-noted  

problems experienced by underrepresented minorities who may wish to  

pursue a career in research.  The program will allow the minority  

investigator to hold a tenure-earning position, to gain additional  

research experience and to obtain preliminary data on which to base  

a subsequent research grant application.



SPECIAL REQUIREMENTS



Applicants are required to have available a recognized expert in the  

area of proposed research for guidance and consultation.  It is  

expected that this expert will assist the applicant in the design  

and conduct of his/her research.  It is not necessary that the  

expert be at the same institution as the applicant, but he/she  

should be within a reasonable proximity to be available for guidance  

and consultation. 



Following the research plan, the applicant is required to provide a  

brief summary of his/her long-term career plans and objectives.  The  

application should state how this award would make a difference in  

and enhance the applicant's development as a scientist.



The department chairman/head should provide a brief paragraph  

indicating his/her plans for the applicant. This official should  

indicate the extent to which time, space and other necessary support  

will be provided to the applicant to conduct the proposed  

investigation(s). A letter from a recognized expert in the area of 

the proposed  research should accompany the application packet.  The 

letter should  attest to his/her willingness to provide counsel and 

advice to the  applicant and an initial plan for ongoing contacts 

with the  applicant.



INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN  

SUBJECTS



It is the policy of the NIH that women and members of minority  

groups and their subpopulations must be included in all NIH  

supported biomedical and behavioral research projects involving  

human subjects, unless a clear and compelling rationale and  

justification is provided that inclusion is inappropriate with  

respect to the health of the subjects or the purpose of the  

research.  This policy results from the NIH Revitalization Act of  

1993 (Section 492B of Public Law 103-43). 



All investigators proposing research involving human subjects should  

read the "NIH Guidelines For Inclusion of Women and Minorities as  

Subjects in Clinical Research,"published in the Federal Register of  

March 28, 1991 (FR59 14508-14513) and in the NIH GUIDE FOR GRANTS  

AND CONTRACTS Volume 23, Number 11, March 18, 1994, available on the  

web at:  http://grants.nih.gov/grants/guide/notice-files/not94-

100.html.



INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN  

SUBJECTS



It is the policy of NIH that children (i.e. individuals under the  

age of 21) must be included in all human subjects' research,  

conducted or supported by the NIH, unless there are scientific and  

ethical reasons not to include them.  This policy applies to all  

initial (Type 1) applications submitted for receipt dates after  

October 1, 1998.



All investigators proposing research involving human subjects should  

read the "NIH Policy and Guidelines on the Inclusion of Children as  

Participants in Research Involving Human Subjects" that was  

published in the NIH GUIDE FOR GRANTS AND CONTRACTS, March 6, 1998,  

and is available at the following URL address:   

http://grants.nih.gov/grants/guide/notice-files/not98-024.html.



Investigators may also obtain copies of these policies from the  

program staff listed under INQUIRIES.  Program staff may also  

provide additional relevant information concerning the policy.



LETTER OF INTENT



Prospective applicants are asked to submit, by February 22, 2000, a  

letter of intent that includes a descriptive title of the proposed  

research, the name, address, and telephone number of the Principal  

Investigator, the identities of other key personnel and  

participating institutions, and the number and title of the RFA in  

response to which the application may be submitted. Although a 

letter of intent is not required, is not binding, and  does not 

enter into the review of a subsequent application, the  information 

that it contains allows NIDDK staff to estimate the  potential 

review workload and avoid conflict of interest in the  review. The 

letter of intent is to be sent to:



Chief, Review Branch

Division of Extramural Activities

National Institute of Diabetes and Digestive and Kidney Diseases

45 Center Drive, Room 6AS-37F, MSC 6600

Bethesda, MD  20892-6600

Telephone:  (301) 594-8885

FAX:  (301) 480-3505



APPLICATION PROCEDURES



Applications are to be submitted on the grant application form PHS  

398 (rev. 4/98).  The form is available at most institutional  

offices of sponsored research, or may be obtained from the Division  

of Extramural Outreach and Information Resources, National  

Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD  

20892-7910, telephone 301/435-0714, email: GrantsInfo@nih.gov.



The modular grant concept establishes specific modules in which  

direct costs may be requested as well as a maximum level for  

requested budgets. Only limited budgetary information is required  

under this approach.  The just-in-time concept allows applicants to  

submit certain information only when there is a possibility for an  

award. It is anticipated that these changes will reduce the  

administrative burden for the applicants, reviewers and Institute  

staff.  The research grant application  form PHS 398 (rev. 4/98) is 

to be used in applying for these grants,  with the modifications 

noted below.



BUDGET INSTRUCTIONS



Modular grant applications will request direct costs in $25,000  

modules, up to a total direct cost request of $50,000 per year.  The  

total direct costs must be requested in accordance with the program  

guidelines and the modifications made to the standard PHS 398  

application instructions described below:



PHS 398



o FACE PAGE: Items 7a and 7b should be completed, indicating Direct  

Costs (in $25,000 increments up to a maximum of $50,000) and Total  

Costs [Modular Total Direct plus Facilities and Administrative (F &  

A) costs] for the initial budget period.  Items 8a and 8b should be  

completed indicating the Direct and Total Costs for the entire  

proposed period of support.



o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD: Do not complete  

Form Page 4 of the PHS 398.  It is not required and will not be  

accepted with the application.



o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT: Do not complete  

the categorical budget table on Form Page 5 of the PHS 398.  It is  

not required and will not be accepted with the application.



o NARRATIVE BUDGET JUSTIFICATION: Prepare a Modular Grant Budget  

Narrative page. (See  

http://grants.nih.gov/grants/funding/modular/modular.htm for sample  

pages.)  At the top of the page, enter the Total Direct Costs  

request for each year.  This is not a Form page.



o Under Personnel, list key project personnel, including their  

names, percent of effort, and roles on the project.  No individual  

salary information should be provided.  However, the applicant  

should use the NIH appropriation language salary cap and the NIH  

policy for graduate student compensation in developing the budget  

request.



o BIOGRAPHICAL SKETCH: The Biographical Sketch provides information  

used by reviewers in the assessment of each individual's  

qualifications for a specific role in the proposed project, as well  

as to evaluate the overall qualifications of the research team.  A  

biographical sketch is required for all key personnel, following the  

instructions below.  No more than three pages may be used for each  

person.  A sample biographical sketch may be viewed at:  

http://grants.nih.gov/grants/funding/modular/modular.htm



-Complete the educational block at the top of the form page;



-List position(s) and any honors;



-Provide information, including overall goals and responsibilities,  

on research projects ongoing or completed during the last three  

years.



-List selected peer-reviewed publications, with full citations.



o CHECKLIST: This page should be completed and submitted with the  

application.  If the F & A rate agreement has been established,  

indicate the type of agreement and the date.  All appropriate  

exclusions must be applied in the calculation of the F & A costs for  

the initial budget period and all future budget years.



o The applicant should provide the name and phone number of the  

individual to contact concerning fiscal and administrative issues if  

additional information is necessary following the initial review.   

The program announcement, title and number must be typed on line 2  

of the face page of the application form and the YES box must be  

marked.



The RFA label available in the PHS 398 (rev. 4/98) application form  

must be affixed to the bottom of the face page of the application.   

Failure to use this label could result in delayed processing of the  

application such that it may not reach the review committee in time  

for review.  In addition, the RFA title and number must be typed on  

line 2 of the face page of the application form and the YES box must  

be marked.



The sample RFA label available at:   

http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been  

modified to allow for this change.  Please note this is in pdf  

format.



Submit a signed, typewritten original of the application, including  

the Checklist, and three signed, exact photocopies, in one package  

to:



CENTER FOR SCIENTIFIC REVIEW

NATIONAL INSTITUTES OF HEALTH 

6701 ROCKLEDGE DRIVE. ROOM 1040 - MSC 7710 

BETHESDA, MD  20892-7710 

BETHESDA, MD  20817 (for express/courier service)



At the time of submission, two additional copies of the application, 

and five copies of any appendix material, must be sent to:



Chief, Review Branch

Division of Extramural Activities

National Institute of Diabetes and Digestive and Kidney Diseases

45 Center Drive, Room 6AS-37F, MSC 6600

Bethesda, MD  20892-6600



Applications must be received by March 22, 2000.  If an application  

is received after that date, it will be returned to the applicant  

without review.  The Center for Scientific Review (CSR) will not  

accept any application in response to this RFA that is essentially  

the same as one currently pending initial review, unless the  

applicant withdraws the pending application.  The CSR will not  

accept any application that is essentially the same as one already  

reviewed.  This does not preclude the submission of substantial  

revisions of applications previously reviewed, but such applications  

must include an introduction addressing the previous critique.



REVIEW CONSIDERATIONS



Applications for the R03 that are complete and responsive to the RFA  

will be evaluated for scientific and technical merit by an  

appropriate peer review group convened by the NIDDK in accordance  

with NIH peer review procedures.  As part of the initial merit  

review, all applications will receive a written critique and undergo  

a process in which only those applications deemed to have the  

highest scientific merit will be discussed, assigned a priority  

score, and receive a second level review by the NIDDK program  

division to which the application has been assigned.



Review Criteria



In the written comments, reviewers will be asked to discuss the  

following aspects of the application in order to judge the  

likelihood that the proposed research will have a substantial impact  

on the pursuit of these goals.  Each of these criteria will be  

addressed and considered in assigning the overall score, weighting  

them as appropriate for each application.  Note that the application  

does not need to be strong in all categories to be judged likely to  

have major scientific impact and thus deserve a high priority score.   

For example, an investigator may propose to carry out important work  

that by its nature is not innovative but is essential to move the  

field forward.



(1) Significance: Does this study address an important problem?  If  

the aims of the application are achieved, how will scientific  

knowledge be advanced?  What will be the effect of these studies on  

the concepts or methods that drive this field?



(2) Approach: Are the conceptual framework, design, methods, and  

analyses adequately developed, well integrated, and appropriate to  

the aims of the project?  Does the applicant acknowledge potential  

problems areas and consider alternative tactics?



(3) Innovation: Does the project employ novel concepts, approaches  

or methods?  Are the aims original and innovative?  Does the project  

challenge existing paradigms or develop new methodologies or  

technologies?



(4) Investigator: Is the investigator appropriately trained and well  

suited to carry out this work?  Is the work proposed appropriate to  

the experience level of the principal investigator and other  

researchers (if any)?



(5) Environment:  Does the scientific environment in which the work  

will be done contribute to the probability of success?  Do the  

proposed experiments take advantage of unique features of the  

scientific environment or employ collaborative arrangements?  Is  

there evidence of institutional support?



In addition to the noted criteria, all applications will also be  

reviewed with respect to the following:



o Adequacy of plans to include both genders, minorities and their  

subgroups, and children as appropriate for the scientific goals of  

the research.  Plans for the recruitment and retention of subjects  

will also be evaluated.



o The adequacy of the proposed protection of humans, animals, or the  

environment, to the extent that they may be adversely affected by  

the project proposed in the application.



o The extent that the proposed research can be completed in the  

project duration, and the potential of the proposed research to  

provide the bases for future studies.



o The applicant's plans and career goals, and the availability of a  

recognized expert in the area of the proposed research for council  

and advice as attested to by a letter of agreement. 



AWARD CRITERIA



The anticipated date of award is September 30, 2000. Applications 

will compete for available funds with all other  applications 

submitted in response to this RFA and recommended by  the initial 

review group.  The following will be considered in  making funding 

decisions:



o Quality of the proposed project as determined by peer review



o Availability of funds



o Program balance among research areas of the RFA.



o The applicant's history of research support.



INQUIRIES



Written and telephone inquiries concerning this RFA are encouraged.   

The opportunity to clarify any issues or questions from potential  

applicants is welcome. Direct inquiries regarding programmatic 

issues to:



Charles H. Rodgers, Ph.D.

Division of Kidney, Urologic and Hematologic Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

45 Center Drive, Room 6AS 19J, MSC 6600

Bethesda, MD  20892-6600

Telephone:  (301) 594-7717

Email:  rodgersc@extra.niddk.nih.gov

 

Judith M. Podskalny, Ph.D.

Division of Digestive Diseases and Nutrition

National Institute of Diabetes and Digestive and Kidney Diseases

45 Center Drive, Room 6AN 12E, MSC 6600

Bethesda, MD  20892-6600

Telephone:  (301) 594-8876

Email:  podskalnyj@extra.niddk.nih.gov

 

Ronald Margolis, Ph.D.

Division of Diabetes, Endocrinology and Metabolism

National Institute of Diabetes and Digestive and Kidney Diseases

45 Center Drive, Room 5AN 12J, MSC 6600

Bethesda, MD  20892-6600

Telephone:  (301) 594-8819

Email:  margolisr@extra.niddk.nih.gov

 

Direct inquiries regarding fiscal matters to:



Ms Nancy C. Dixon

Chief, Grants Management Branch

Division of Extramural Activities

National Institute of Diabetes and Digestive and Kidney Diseases

45 Center Drive, Room 6AN 44C, MSC 6600

Bethesda, MD  20892-6600

Telephone:  (301) 594-8854

Email:  dixonn@extra.niddk.nih.gov

 

Schedule



Letter of Intent Receipt Date: February 22, 2000 

Application Receipt Date: March 22, 2000

Technical/Scientific Review: June/July, 2000

Review by Divisions/NIDDK: September 2000

Anticipated Award Date: September 30, 2000



KEYWORDS:

Keycode Keyword

A000750 National Institute of Diabetes and Digestive and Kidney Diseases

00000FF Minorities

00000A1 Target Groups & Beneficiaries

00000FA Minorities, Alaskans

00000FB Minorities, Asians

00000FC Minorities, Blacks

00000FD Minorities, Hispanics

00000FE Minorities, Native Americans

0715075 Diabetes

071500A All Disease Entities & Medical Problems & Behavior

0700000 Health & Safety, Medical & Biomedical Sciences

0715000 Disease Entities & Medical Problems

071000A All Disciplines & Fields, Health & Safety, Medical & Biomedical

0710000 Disciplines & Fields, Health & Safety, Medical & Biomedical

0715085 Digestive Diseases & Disorders

0705025 Digestive System

070500A All Anatomical Systems & Sites

0715133 Kidney Disease

0705000 Anatomical Systems & Sites

0745027 Disease Prevention

074500A All Intervention, Types of (Health Safety & Medical)

0785050 Endocrinology

078500A All Specialties of Medical & Allied Fields

0785070 Hematology

0765020 Metabolism

076500A All Natural Processes (Health & Safety & Medical)

0000034 Research

0730070 Public Health

073000A All Health Care

0785220 Urology

0745000 Intervention, Types of (Health & Safety & Medical)

0785000 Specialties of Medical & Allied Fields

0765000 Natural Processes (Health & Safety & Medical)

078000A All Research Resources (Health & Safety & Medical)

0780010 Biomedical Research Resources, Other

0780000 Research Resources (Health & Safety & Medical)

0710095 Nutrition & Dietetics

0710030 Biomedical Research, Multidisciplinary

0783005 Human Subjects Policy


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